2017 Fiscal Year Final Research Report
Thermoreversible gel disc assay of rat angiogenesis
Project/Area Number |
25450473
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Integrative animal science
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Research Institution | Azabu University |
Principal Investigator |
wakui shin 麻布大学, 獣医学部, 准教授 (40201157)
|
Project Period (FY) |
2013-04-01 – 2018-03-31
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Keywords | 血管新生 / 微小循環学 |
Outline of Final Research Achievements |
Endothelial cells and pericytes play critical role in angiogenesis, which is controlled, in part, by the angiopoietin (Ang)/Tie-2 system and vascular endothelial growth factor (VEGF). Endothelial cell and pericyte interdigitations(EPI), consisting of cytoplasmic projections of pericytes and corresponding endothelial indentations, are frequently present at angiogenic sites. After subcutaneous implantation of a thermoreversible gelation polymer disc in rats, the capillary density was low on day 5, increased to a peak on day 7, and then decreased on days 10-20. A small number of EPI were observed on day 5, then increased sharply to a peak on day 10, but had decreased on day 20.
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Free Research Field |
微小循環学
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