2015 Fiscal Year Final Research Report
Development of Synthetic Methods for Heterocycles Using Transition-Metal Catalyzed C-H Functionalization
| Project/Area Number |
25460002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Mukogawa Women's University (2014-2015)
Tohoku University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 触媒・化学プロセス / 有機化学 / 遷移金属 / C-H 官能基化 / 複素環化合物 |
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| Outline of Final Research Achievements |
Catalytic carbonylative C-H cyclization of 2-arylphenols can be achieved in the presence of a ruthenium-based catalytic system. The process proceeds efficiently under balloon pressure of CO and produces variously substituted 6H-dibenzo[b,d]pyran-6-one compounds, typically in good to high yields. In addition, a novel synthetic procedure for the construction of the xanthine framework has been developed by using a copper catalyst. Furthermore, enantioselective C-H cyclization via desymmetrization was also examined. However, the product obtained was a mixture of racemic compounds.
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| Free Research Field |
医歯薬学
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