Formulation design of pharmaceutical emulsions based on magnetic resonance imaging and quality-by-design approach

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460045
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: University of Toyama (2015); Hoshi University (2013-2014)
• Principal Investigator: Onuki Yoshinori 富山大学, 大学院 医学薬学研究部(薬学), 客員教授 (10350224)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: MRI / クリーム剤 / 製剤安定性 / QbD

Outline of Final Research Achievements

Physical stability is an important quality attribute of pharmaceutical emulsions. In general, the physical stability is affected by various factors in a complicated manner. Since the quality-by-design concept was issued, the importance of understanding the relationships between formulation variables and responses has been expanding in the development of pharmaceuticals. The purpose of this study is to gain a comprehensive understanding of the physical stability of pharmaceutical emulsions. The key technology used to evaluate the state of water was magnetic resonance imaging (MRI). From the findings, formulation variables had a significant impact on the state of water in the model formulations. Furthermore, it was clarified that the state of water played an important role in the stability of the model emulsions. In conclusion, we succeeded in gaining a comprehensive understanding of the physical stability of the model emulsions and establishing conditions to prepare stable emulsions.

Free Research Field

物理系薬学