Study on the neurodevelopmental abnormalities induced by the innate immune activation during perinatal period

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460093
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pharmacology in pharmacy
• Research Institution: Nagoya University
• Principal Investigator: NAGAI Taku 名古屋大学, 医学部附属病院, 准教授 (10377426)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 神経発達 / アストロサイト / 免疫

Outline of Final Research Achievements

Polyriboinosinic-polyribocytidilic acid (polyI:C) is known to induce strong innate immune responses that mimic immune activation by viral infections. Our previous findings suggest that the induction of interferon-induced transmembrane 3 (Ifitm3) in astrocytes has a crucial role in polyI:C-induced neurodevelopmental abnormalities including impairments of dendrite elongation and spine formation, which lead to behavioral impairments in adulthood. Through a quantitative proteomic screen, we identified the candidate proteins of astroglial factors, matrix metalloproteinase-3 (Mmp3) and follistatin like-1 (Fstl1), and Mmp3 function on neuronal development was reported previously. In this study, we characterized the effect of Fstl1 on neuronal development and relationship of Ifitm3 expression. Our results suggest that astroglial Fstl1 is one of possible mediators for neurodevelopmental impairment and the extracellular levels of Fstl1 may be regulated under the control of Ifitm3.

Free Research Field

神経精神薬理学