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2015 Fiscal Year Final Research Report

Role of the 5-HT4 receptor in neurogenic activity of chronic fluoxetine in the dentate gyrus and its association with mature granule cell dematuration

Research Project

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Project/Area Number 25460096
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pharmacology in pharmacy
Research InstitutionTokyo University of Science (2015)
Kyoto University (2013-2014)

Principal Investigator

SEGI ERI  東京理科大学, 基礎工学部, 准教授 (70378628)

Co-Investigator(Renkei-kenkyūsha) KOBAYASHI KATSUNORI  日本医科大学, 医学部, 准教授 (10322041)
Research Collaborator IMOTO YUKI  
Project Period (FY) 2013-04-01 – 2016-03-31
Keywords海馬 / 抗うつ薬 / 神経神経 / セロトニン受容体
Outline of Final Research Achievements

Chronic treatment with selective serotonin (5-HT) reuptake inhibitors (SSRIs) facilitates adult neurogenesis in the dentate gyrus (DG) of the hippocampus. However, it is largely unknown how the 5-HT4 receptor mediates neurogenic effects in the DG. I addressed this issue using 5-HT4 receptor knockout (5-HT4R KO) mice. Expression of the 5-HT4 receptor was detected in mature GCs but not in neuronal progenitors of the DG. Chronic treatment with the SSRI fluoxetine significantly increased cell proliferation and the number of doublecortin-positive cells in the DG of wild-type mice, but not in 5-HT4R KO mice. I also demonstrated that fluoxetine-induced adult neurogenesis and granule cell dematuration are closely associated, providing new insight into the cellular mechanisms of the neurogenic actions of SSRIs in the hippocampus.

Free Research Field

医歯薬学

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Published: 2017-05-10  

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