Anti-NTDs compounds from tropical medicinal plants

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460126
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Natural medicines
• Research Institution: University of Shizuoka
• Principal Investigator: Umehara Kaoru 静岡県立大学, 薬学部, 講師 (40185070)
• Co-Investigator(Kenkyū-buntansha): YASUMOTO Kanami 徳島文理大学, 香川薬学部, 助教 (70412393) ; SUZUKI Takashi 静岡県立大学, 薬学部, 教授 (20240947) ; HIDARI Kazuya 会津大学, 短期大学部, 教授 (20260226)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: medicinal plant / NTD / dengue / leishmania / flavonoid / lignan

Outline of Final Research Achievements

Isoflavonoids isolated from a Thai medicinal plant, Dalbergia parviflora, were recognized as having their potentials for new anti-NTDs phytochemicals. Cajanin and medicarpin showed strong anti-dengue activity and suppressed more than 50% of dengue virus type 2 (DENV-2) infection at concentrations of 10 μM through in vitro anti DENV-2 infection assay. Cajanin was proposed to have multiple mechanisms to inhibit virus infection because it is known to inhibit α-glucosidase, which has a critical role in viral maturation by initiating the processing of N-linked oligosaccharides of viral envelope glycoproteins.
Genistein and isoliquiritigenin showed strong leishmanicidal activity at concentrations less than 20 μM.
Extracts of the Bangladeshi medicinal plant Terminalia citrina (Combretaceae) were isolated, and 56 lignans were characterized. The isolates were evaluated their anti-estrogenic activity. And some lignan aglycones showed leishmanicidal activity.

Free Research Field

天然物化学