Antitumor natural products targeting PPAR-gamma and their combination effect with clinically used anticancer agents

2016 Fiscal Year Final Research Report

• Project/Area Number: 25460134
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Natural medicines
• Research Institution: Tokyo University of Pharmacy and Life Science
• Principal Investigator: Mimaki Yoshihiro 東京薬科大学, 薬学部, 教授 (90229790)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: PPAR-gamma / Santalum album / セスキテルペン / 選択的腫瘍細胞毒性 / カンゾウ / プレニルイソフラボノイド誘導体 / ビャクシ / 新規クマリン誘導体

Outline of Final Research Achievements

Magnolol, a natural PPAR-gamma agonist, enhanced the tumor selective cytotoxic activity of a new sesquiterpene from Santalum album heart wood against HL-60 leukemia cells by more than 100 times. Furthermore, a prenylisoflavonoid derivative from Glycyrrhiza glabra roots and a new coumarin derivative from Angelica dahurica roots exhibited PPAR-gamma agonist activity and attenuated the cytotoxicity of etoposide, a clinically used anticancer agent, against A549 lung adenocarcinoma cells. The kampo prescription of Shimpito Extract and Ephedra Herb extract showed PPAR-gamma agonist activity. Three prenylfuranocoumarin derivatives were isolated from Glehnia littoralis roots and rhizomes as the PPAR-gamma agonists.

Free Research Field

薬用資源学