2016 Fiscal Year Final Research Report
Structure activity relationships study of dual-core type acetogenin analogues for development of novel antitumor agents
Project/Area Number |
25460159
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Drug development chemistry
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Research Institution | Kyoto Pharmaceutical University |
Principal Investigator |
Kojima Naoto 京都薬科大学, 薬学部, 准教授 (90420413)
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Keywords | 抗がん剤 / 有機合成化学 / 構造活性相関研究 / 生物活性物質 |
Outline of Final Research Achievements |
We reported that heterocycle-introduced analogues in the place of lactone ring as a common structure of annonaceous acetogenins, potently inhibit the growth of human cancer cell lines. Especially, a thiophen analog showed potent antitumor activity in in vivo assay using xenograft mice. In this work, we planned to synthesis of dual-core type analogues those have two heterocycles at the both ends of those. As a result, it was revealed that dual-core type analogue shows as potent inhibitory activity as the mother compound, indicating that dual-core type analogues may be a novel lead compound for antitumor agents.
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Free Research Field |
創薬化学
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