2015 Fiscal Year Final Research Report
Influence of genetic polymorphisms on antidepressant response or maintenance dose in Japanese individuals with depression
| Project/Area Number |
25460191
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 抗うつ薬 / 維持量 / うつ病 / 遺伝子多型 |
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| Outline of Final Research Achievements |
This study was conducted to examine genetic polymorphisms associated with antidepressant response or maintenance dose setting for antidepressant therapy in Japanese individuals with depression. I assessed antidepressant response using antidepressant cessation by exacerbation or control of depressive symptoms. In addition, I calculated the maintenance dose using the imipramine equivalent scale. I found that the presence of CREB1 rs4675690 polymorphism may be associated with the response to selective serotonin-reuptake inhibitors; in addition, the concomitant diazepam equivalent dose and the presence of the CREB1 rs4675690 polymorphism were associated with antidepressant maintenance doses.
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| Free Research Field |
薬理遺伝学
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