2015 Fiscal Year Final Research Report
Development of a novel experimental evaluation method for predicting the drug delivery to the brain in human
| Project/Area Number |
25460199
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKURA TAKASHI 帝京大学, 薬学部, 准教授 (80326123)
HIGUCHI KEI 帝京大学, 薬学部, 助教 (10625304)
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| Co-Investigator(Renkei-kenkyūsha) |
HOSOYAMADA MAKOTO 帝京大学, 薬学部, 教授 (00291659)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 血液脳関門 / ヒト脳移行性 / トランスポーター / 有機カチオン性薬物 / ヒト血液脳関門モデル細胞 / 循環培養システム |
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| Outline of Final Research Achievements |
The objectives of this study are to develop reliable experimental-method(s) for predicting functions of human blood-brain barrier (BBB), using hCMEC/D3 cells, an in vitro human BBB model. As for the research achievements, 1) the in vitro cocktail dosing method could be developed for evaluating the human BBB function. In addition, in vivo microdialysis method with cocktail-dosing could be developed. The latter method will be important for making the preclinical study more efficient. 2) We could gain the important information about a novel and flow-based cultivation method with shear stress.
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| Free Research Field |
薬物動態学
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