2015 Fiscal Year Final Research Report
Construction of the experimental model for assessment of motivation using rat intracranial self-stimulation model
| Project/Area Number |
25460212
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 脳内自己刺激行動 / 意欲 / Phasic firing |
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| Outline of Final Research Achievements |
In the present study, we constructed the experimental model using the intracranial self-stimulation to evaluate "motivation" and assessed the impact of drug administration on the motivation. The intracranial self-stimulation behavior is one of the experimental method for the assessment of brain reward function.As a result, it was demonstrated that brain dopamine nerves showed an important role in motivation, and that amplifying the action of dopamine which was released from the nerve terminal would be important in improving motivation. In addition, it was suggested that the brain nerve cell was possibility activated by the acquisition of motivated behavior.
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| Free Research Field |
臨床薬学
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