Pharmacokinetic/pharmacodynamic investigation for BPSD in dementia patients receiving donepezil.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460215
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: University of Shizuoka
• Principal Investigator: Kagawa Yoshiyuki 静岡県立大学, 薬学部, 教授 (90397505)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Yoshiaki 国立病院機構, 静岡てんかん神経医療センター, 治験管理室主任 (60596245)
• Research Collaborator: SAKAKIBARA Ayami
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: donepezil / BPSD / dementia

Outline of Final Research Achievements

Behavioral and psychological symptoms of dementia (BPSD) are big problem for the treatment of dementia. We investigated relationship between plasma concentration of donepezil, the most popular drug for dementia and the development of BPSD. First we developed the highly sensitive LC-MS/MS method for donepezil and its active metabolite, 6-O-desmethyldonepezil. Using this method we achieved the quantitation limits of both two drugs under 0.1 ng/mL. In the clinical study, although plasma concentration of 6-O-desmethyldonepezil did not correlated with development of BPSD, patients whose plasma concentration of donepezil were above 75 ng/mL did not developed BPSD. These results indicated that plasma concentration of donepezil influences the development of BPSD.

Free Research Field

臨床薬剤学