Estimation of bitterness intenisty of drug using IAsys

2016 Fiscal Year Final Research Report

• Project/Area Number: 25460234
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Mukogawa Women's University
• Principal Investigator: yoshida miyako 武庫川女子大学, 薬学部, 准教授 (20369028)
• Co-Investigator(Renkei-kenkyūsha): HAZEKAW Mai 福岡大学, 薬学部, 助教 (10509186) ; HARAGUCHI Tamami 武庫川女子大学, 薬学部, 助教 (10550741)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: bitterness intensity

Outline of Final Research Achievements

The interaction of T2R which was a bitterness receptor of the Homo sapiens and bitter drugs was evaluated by SPRNavi . The affinity was evaluated as bitterness intensity of drug. At first, as a standard drug of the bitterness, quinine hydrochloride to use as a sample (standard sample) was used for establishment of quantative bitterness measurement condition. Correlation bitween affinity and gustatory sensation test was also evaluated. Affinity with T2R14 was suggested to be high for the high hydrophobic drug and these drugs suggested to have strong bitterness.

Free Research Field

臨床製剤学