Sequential morphogenetic changes of lymphatic endothelium caused by molecular genetic cues

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460249
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Iwate Medical University
• Principal Investigator: ISOGAI SUMIO 岩手医科大学, 医学部, 准教授 (60212966)
• Co-Investigator(Kenkyū-buntansha): SHIMODA HIROSHI 弘前大学, 医学研究科, 教授 (20274748)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: リンパ管 / 小型魚類

Outline of Final Research Achievements

As well known, lymph-endothelial cells are originated from venous endothelia in zebrafish and medaka embryos. We investigated sequential phenotypic changes which are closely related with the molecular genetic changes to become the lymph endothelium from the venous endothelium.
1. We compiled the anatomical atlas of lymph vascular systems in zebrafish and medaka from embryos through adults.2. We investigated the sequential morphogenetic changes of lymph-endothelial cells with Arrey Tomography.3. Using VEGFR3 mutant zebrafish, we analyzed developmental mechanisms of cervical lymph-sac.

Free Research Field

発生学・形態形成学