Genetic and cellular characteristics of the pre-placodal region

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460252
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Jichi Medical University
• Principal Investigator: SATO Shigeru 自治医科大学, 医学部, 准教授 (70306108)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 感覚器形成 / プラコード / 転写制御 / マウス / ニワトリ / アフリカツメガエル / 内耳 / 嗅上皮

Outline of Final Research Achievements

The aim of this study was to understand genetic and cellular characteristics of the sensory placodes and their precursor domain (PPR). 1) All materials required for the identification of Six1-target genes were prepared. 2) The PPR-specific enhancer of Xenopus Six1 was characterized. 2) Two new mouse lines expressing Cre under the control of two placode-specific Six1 enhancers were developed. 4) Cell ablation experiments were carried out using the two Cre-expressing mouse lines. The above results provided novel information on the regulation and function of Six1 and Six1-expressing cells, and should advance our understandings on the sensory organogenesis.

Free Research Field

発生生物学