Analyses of protein complex in Schwann cell membrane skeletal structures

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460267
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Shinshu University
• Principal Investigator: TERADA Nobuo 信州大学, 学術研究院保健学系, 教授 (60293461)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 膜骨格 / シュワン細胞 / 凍結技法 / 末梢神経系

Outline of Final Research Achievements

We clarified that a membrane skeletal 4.1 family, 4.1G, is involved in Schmidt-Lanterman incisure in myelin of Schwann cells, and have roles in sorting of membrane protein palmitoylated (MPP) 6, cell adhesion molecule (CADM) 4 and phosphorylation of Src. In vivo cryotechnique revealed beaded appearance and protective reaction of the incisures in stretched peripheral nerve fibers, as well as accurate localization of albumin. In addition, we analyzed relationship between the 4.1 and MPP families in mouse intestinal epithelial cells.

Free Research Field

細胞組織学