2015 Fiscal Year Final Research Report
Analysis of the transcription factor crosstalk in high endothelial venule formation
| Project/Area Number |
25460268
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Kinki University (2015)
Osaka University (2013-2014) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 血管内皮細胞 |
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| Outline of Final Research Achievements |
The high endothelial venules (HEVs) are specialized blood vessels that permit lymphocyte trafficking across their endothelial cells (ECs) and develop in a tissue-specific manner. We previously found that a transcription factor X is preferentially expressed in immature HEV-ECs of lymph nodes and Peyer's patches. We found that neonatal HEVs in the gene X -knockout (KO) mice express lower levels of HEV-EC marker proteins than wild type littermates. In contrast, postnatal HEVs in the gene X-transgenic mice showed an increase in HEV-EC marker proteins. These results support the hypothesis that the gene X contributes to HEV-EC differentiation.
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| Free Research Field |
細胞生物学
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