Functional coupling between ion channels and scramblases in human TMEM16F-expressing cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460282
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: University of Toyama
• Principal Investigator: SHIMIZU TAKAHIRO 富山大学, 大学院医学薬学研究部(薬学), 准教授 (40353437)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: TMEM16F / イオンチャネル / スクランブラーゼ

Outline of Final Research Achievements

It has been recently identified that the transmembrane protein (TMEM) 16A functions as a calcium-activated anion channels. On the other hand, TMEM16F, a member of the TMEM16 family, is demonstrated to transport phospholipids as a scramblase. We demonstrated, in the present study, that TMEM16F functions as not only phospholipid scramblases but also calcium-activated anion channels. In addition, we clarified that both TMEM16F functions are closely related. We therefore suggested that TMEM16F is a unique membrane protein exhibiting two different membrane transports.

Free Research Field

細胞分子生理学