Ion channel involved in stress-response and anxiety-like behavior

2016 Fiscal Year Final Research Report

• Project/Area Number: 25460323
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Kurashiki University of Science and the Arts (2015-2016); Kansai Medical University (2013-2014)
• Principal Investigator: Okada Masayoshi 倉敷芸術科学大学, 生命科学部, 教授 (40334677)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: K+ チャネル / TREK / うつ / 不安

Outline of Final Research Achievements

We have screened botanical compounds and found a novel 2-pore-domain type K+ channel activator with patch-clamp recordings. This compound showed both anxiolytic and antidepressive effects in the mouse behavior tests. The compound had no effect on anti-c-fos immunoreactivity in the brain of nontreated-mouse but suppressed a stress-induced increase in the anti-c-fos immunoreactivity in a nucleus. This site of action was different from those of current anxiolytic or antidepressant, suggesting a novel mechanism this compound.
We also revealed the involvement of intracellular transport in the run-up of TREK-1 channel current.

Free Research Field

神経科学