2015 Fiscal Year Final Research Report
Examination of the in vivo effect of DIF, an inhibitor of G1 phase transition derived from Dictyostelium, as a new anti-cancer drug
| Project/Area Number |
25460334
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kyushu University |
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Principal Investigator |
Takahashi Fumi 九州大学, 医学(系)研究科(研究院), 講師 (50274436)
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| Co-Investigator(Renkei-kenkyūsha) |
IGAWA KAZUNOBU 九州大学, 先導物質化学研究所, 助教 (80401529)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 新規抗腫瘍薬 / 経口抗腫瘍薬 |
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| Outline of Final Research Achievements |
We reported that differentiation-inducing factor-1 (DIF-1), synthesized by Dictyostelium discoideum, inhibited proliferation of various tumor cell lines in vitro. However, it remained unexplored whether DIF-1 also inhibits tumor growth in vivo. In the present study, therefore, we examined in-vivo effects of DIF-1 using three cancer models: Mutyh-deficient mice with oxidative stress-induced intestinal tumors and nude mice xenografted with cancer cells, and lung metastasis model mice.
We found that oral administrated DIF-1 significantly suppressed tumor growth in all examined models.
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| Free Research Field |
分子薬理学
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