Analyses of the generation mechanisms for the bioactive lipids N-acylethanolamines

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460370
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Kagawa University
• Principal Investigator: UEDA Natsuo 香川大学, 医学部, 教授 (20193807)
• Co-Investigator(Kenkyū-buntansha): UYAMA Toru 香川大学, 医学部, 助教 (30457337) ; TSUBOI Kazuhito 香川大学, 医学部, 助教 (80346642)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: アシルトランスフェラーゼ / アナンダミド / オレオイルエタノールアミド / 酵素 / 脂質メディエーター / 脂肪酸エタノールアミド / パルミトイルエタノールアミド / リン脂質

Outline of Final Research Achievements

N-Acylethanolamines (NAEs) are enzymatically formed from phospholipids in animal tissues and function as lipid mediators. We showed that phospholipase A/acyltransferase-1 (PLAAT-1) acts as N-acyltransferase generating N-acyl-phosphatidylethanolamines (NAPEs), precursors of NAEs in living cells and that glycerophosphodiesterase 4 (GDE4) produces NAEs from lysoNAPEs as a lysophospholipase D.

Free Research Field

生化学