2015 Fiscal Year Final Research Report
Study on the mechanism of cell growth regulation by ST2 and its possible anti-cancerous effect.
| Project/Area Number |
25460393
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAGO KENJI 自治医科大学, 医学部, 講師 (20306111)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | ST2 / IL-33 / 線維芽細胞 / 細胞増殖 / NIH-3T3 cells / シグナル伝達 / 分泌 |
|---|
| Outline of Final Research Achievements |
The ST2 gene was originally identified as a gene induced during the initiation of cell proliferation. Since the products had a sequence very similar to the interleukin 1 receptor and IL-33 was found as a ligand inducing inflammatory responses, the major concern has been immunological aspect. In the present study, coming back to the original findings, we investigated the roles of IL-33 and ST2 in cell proliferation of NIH-3T3 fibroblastic cell line. IL-33 had dual functions, namely, a suppressive effect on the growth initiation of quiescent cells, and a growth-promoting effect on cycling cells. On the other hand, contrary to the initial hypothesis, soluble ST2 had a growth-promoting effect.
The relationship between IL-33 and ST2 in terms of growth regulation remains to be elucidated in future.
|
| Free Research Field |
生化学
|
