Physiome research of systemic metabolism affected by brtain neuroinflammation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460399
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Kataoka Yosky 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー (40291033)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 疲労 / 代謝 / 脳 / 炎症 / 肝臓

Outline of Final Research Achievements

Fatigue loading induced the dysfunction of energy metabolism in the rat lever. This research revealed that such a fatigue condition induced the fatigue-specific metabolism in the liver. While this fatigue-specific metabolism increased ATP production under fatigue condition, it induced tissue inflammation by the production of proinflammatory cytokines in the liver. Such a peripheral inflammation was suggested to trigger neuroinflammation in the brain involved in fatigue sensation.

Free Research Field

生理学