2015 Fiscal Year Final Research Report
Physiome research of systemic metabolism affected by brtain neuroinflammation
Project/Area Number |
25460399
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pathological medical chemistry
|
Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
Kataoka Yosky 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー (40291033)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | 疲労 / 代謝 / 脳 / 炎症 / 肝臓 |
Outline of Final Research Achievements |
Fatigue loading induced the dysfunction of energy metabolism in the rat lever. This research revealed that such a fatigue condition induced the fatigue-specific metabolism in the liver. While this fatigue-specific metabolism increased ATP production under fatigue condition, it induced tissue inflammation by the production of proinflammatory cytokines in the liver. Such a peripheral inflammation was suggested to trigger neuroinflammation in the brain involved in fatigue sensation.
|
Free Research Field |
生理学
|