Molecular mechanisms of serrated pathway in colorectal cancer pathogenesis and their application to diagnosis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460416
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Hiroshima University
• Principal Investigator: Sentani Kazuhiro 広島大学, 医歯薬保健学研究院(医), 講師 (30508164)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 大腸発癌

Outline of Final Research Achievements

Expression of SPC18 and BST2, identified from the gene databases of gastrointestinal cancer, were observed in about half of colorectal cancer (CRC). There was a significant correlation of their expressions with high stage and poor prognosis, and both molecules promoted the ability of proliferation and invasion in CRC. These molecules expressed more frequently in CRC and precancerous lesions of classical pathway than those in serrated pathway. These results indicated that SPC18 and BST2 might be a crucial molecules involving in the differences of both pathways.
In addition, we clarified the significance of MMP-7, lamininγ2 and EGFR at the invasive front of gastric cancer and their association with tumor aggressiveness.

Free Research Field

人体病理