2015 Fiscal Year Annual Research Report
ER、PgR、HER2発現に基づいた子宮類内膜腺癌の臨床病理学的分子レベルの解析
| Project/Area Number |
25460420
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| Research Institution | Iwate Medical University |
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Principal Investigator |
菅井 有 岩手医科大学, 医学部, 教授 (20187628)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 類内膜腺癌 / 遺伝子変異 / KRAS / p53 / PIK3CA / メチル化 / LOH |
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| Outline of Annual Research Achievements |
本研究の目的は、エストロゲンレセプター（ER）、プロゲステロンレセプター（PgR）、HER2の発現を基に、類内膜腺癌の分離癌腺管の形質を4つのタイプ（A型；ER陽性もしくはPgR陽性かつHER2陰性；B型ER陽性もしくはPgR陽性かつHER2陽性；C型：ER陰性かつPgR陰性かつHER2陰性；D型いずれも陰性）に分類して臨床病理学的、分子病理学的な差異を明らかにし、これらの分類の妥当性について検証した。Type A, Bの進行期分類ではI, II期が多く、type C, DのそれではIII期、IV期が多い傾向があった。PTENの発現低下はいずれのtypeにもみられたが、type Cで特に発現低下を示す症例が少なかった。KRAS変異はtype Cに多く、PIK3CA変異はtype A, Bに多い傾向がみられた。LOH状態はtype C, Dに多かったが、MSIは共通していた。メチル化状態は各形質で共通していたが、出現パターンは異なっていた。本分類は類内膜癌の発癌機序を考える上で有用と思われた。
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[Journal Article] Endoscopic Findings of Small-Bowel Lesions in Familial Amyloid Polyneuropathy: A Case Report.2016
Author(s)
Asakura K, Yanai S, Nakamura S, Kawaski K, Eizuka M, Ishida K, Sugai T, Ueda M, Yamashita T, Ando Y, Matsumoto T.
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Journal Title
Medicine (Baltimore)
Volume: 95(11)
Pages: e2896-2896
DOI
Peer Reviewed / Open Access
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[Journal Article] Dabigatran-induced esophagitis: The prevalence and endoscopic characteristics.2016
Author(s)
Toya Y, Nakamura S, Tomita K, Matsuda N, Abe K, Abiko Y, Orikasa S, Akasaka R, Chiba T, Uesugi N, Sugai T, Matsumoto T.
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Journal Title
J Gastroenterol Hepatol
Volume: 31(3)
Pages: 610-614
DOI
Peer Reviewed / Open Access
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[Journal Article] Neural cell adhesion molecule (CD56)-positive B cell lymphoma of the urinary bladder.2016
Author(s)
Kawasaki T, Suzuki M, Sato A, Yashima-Abo A, Satoh T, Kato R, Kato Y, Obara W, Shimoyama T, Ishida Y, Sugai T.
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Journal Title
J Clin Pathol
Volume: 69(1)
Pages: 89-92
DOI
Peer Reviewed / Open Access
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[Journal Article] Chaperone protein l-isoaspartate (d-aspartyl) O-methyltransferase as a novel predictor of poor prognosis in lung adenocarcinoma.2016
Author(s)
Saito H, Yamashita M, Ogasawara M, Yamada N, Niisato M, Tomoyasu M, Deguchi H, Tanita T, Ishida K, Sugai T, Yamauchi K.
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Journal Title
Hum Pathol
Volume: 50
Pages: 1-10
DOI
Peer Reviewed / Open Access
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[Journal Article] Analysis of a single-codon E746 deletion in exon 19 of the epidermal growth factor receptor.2016
Author(s)
Ogasawara M, Nakamura Y, Morikawa N, Nitanai H, Moriguchi S, Chiba R, Saito H, Ohta M, Tanita T, Sugai T, Maeyama K, Yamauchi K, Takaoka Y.
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Journal Title
Cancer Chemother Pharmacol
Volume: 77(5)
Pages: 1019-1029
DOI
Peer Reviewed / Open Access
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[Journal Article] Well-differentiated neuroendocrine tumor of the breast with recurrence due to needle tract seeding.2015
Author(s)
Kawasaki T, Ishida M, Tada T, Matsuya H, Saitoh M, Sato A, Suzuki M, Sugimoto R, Mue Y, Uesugi N, Ishida K, Ariga H, Ichihara S, Sugai T, Sapino A.
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Journal Title
Virchows Arch
Volume: 466(4)
Pages: 479-481
DOI
Peer Reviewed / Open Access
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[Journal Article] Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors.2015
Author(s)
Kamimae S, Yamamoto E, Kai M, Niinuma T, Yamano HO, Nojima M, Yoshikawa K, Kimura T, Takagi R, Harada E, Harada T, Maruyama R, Sasaki Y, Tokino T, Shinomura Y, Sugai T, Imai K, Suzuki H.
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Journal Title
Oncotarget
Volume: 6(30)
Pages: 29975-29990
DOI
Peer Reviewed / Open Access
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[Journal Article] Significance of a white opaque substance under magnifying narrow-band imaging colonoscopy for the diagnosis of colorectal epithelial neoplasms.2015
Author(s)
Kawasaki K, Kurahara K, Yanai S, Oshiro Y, Eizuka M, Uesugi N, Ishida K, Nakamura S, Fuchigami T, Sugai T, Matsumoto T.
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Journal Title
Gastrointest Endosc.
Volume: 82(6)
Pages: 1097-1104
DOI
Peer Reviewed
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[Journal Article] Lymphangiogenic factors are associated with the severity of hypersensitivity pneumonitis.2015
Author(s)
Yamashita M, Mouri T, Niisato M, Nitanai H, Kobayashi H, Ogasawara M, Endo R, Konishi K, Sugai T, Sawai T, Yamauchi K.
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Journal Title
BMJ Open Respir Res.
Volume: 2(1)
Pages: e000085-000085
DOI
Peer Reviewed / Open Access
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[Journal Article] Non-Islet Cell Tumor Hypoglycemia Is Caused by Big IGF-II in a Patient with a Carcinosarcoma of the Uterus.2015
Author(s)
Honma H, Takahashi Y, Matsui M, Satoh T, Fukuda I, Takahashi K, Takebe N, Nagasawa K, Ono M, Sasai T, Kajiwara T, Sugai T, Satoh J, Ishigaki Y.
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Journal Title
Intern Med
Volume: 54(24)
Pages: 3165-3169
DOI
Peer Reviewed / Open Access
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[Journal Article] Clinicopathological and molecular alterations in early gastric cancers with the microsatellite instability-high phenotype.2015
Author(s)
Sugimoto R, Sugai T, Habano W, Endoh M, Eizuka M, Yamamoto E, Uesugi N, Ishida K, Kawasaki T, Matsumoto T, Suzuki H.
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Journal Title
Int J Cancer
Volume: 138(7)
Pages: 1689-1697
DOI
Peer Reviewed / Open Access
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[Presentation] Massive myoepithelial hyperplasia (myoepitheliosis) with lumpy deposits of basement membrane material closely associated with apocrine adenosis and ductal carcinoma in SITU of the breast.2015
Author(s)
Tomonori K, Ayaka S, Toshio O, Hiroshi N, Kazushige F, Masayuki I, Takuya M, Hiroko T, Shu I, Tamotsu S, Ryohei K
Organizer
27th European Congress of Pathology
Place of Presentation
セルビア
Year and Date
2015-09-05 – 2015-09-09
Int'l Joint Research
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[Presentation] Microinvasive neuroendocrine carcinoma arising from central papilloma of the breast.2015
Author(s)
Tomonori K, Ayaka S, Masao S, Hiroko T, Suzuko M, Shu I, Hideko Y, Noriyuki U, Tamotsu S, Anna S, Ryohei K
Organizer
27th European Congress of Pathology
Place of Presentation
セルビア
Year and Date
2015-09-05 – 2015-09-09
Int'l Joint Research
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[Presentation] High prevalence of solid papillary carcinoma with neuroendocrine differetiation in breast lesions detedted by the clinical symptom of bloody nipple discharge.2015
Author(s)
Tomonori K, Ayaka S, Masao S, Yusuke M, Kazushige I, Masahiro K, Shu I, Hiroshi Y, Hideko Y, Tamotsu S, Anna S
Organizer
27th European Congress of Pathology
Place of Presentation
セルビア
Year and Date
2015-09-05 – 2015-09-09
Int'l Joint Research
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[Presentation] Glycogen-rich clear cell carcinoma of the breast showing carcinomatous lymphangiosis and extremely aggressive clinical behavior.2015
Author(s)
Ayaka S, Tomonori K, Yoshiharu M, Kazushige I, Masahiro K, Makiko T, Hisanori A, Hideaki K, Suzuko M, Shu I, Tamotsu S
Organizer
27th European Congress of Pathology
Place of Presentation
セルビア
Year and Date
2015-09-05 – 2015-09-09
Int'l Joint Research
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[Presentation] Well-differentiated neuroendocrine tumour of the breast with recurrence due to needle tract seeding.2015
Author(s)
Ayaka S, Tomonori K, Motoo I, Takashi T, Hideki M, Shu I, Makiko T, Hisanori A, Masamichi S, Tamotsu S, Anna S
Organizer
27th European Congress of Pathology
Place of Presentation
セルビア
Year and Date
2015-09-05 – 2015-09-09
Int'l Joint Research
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[Presentation] Cytological features of pleomorphic/necrotic lobular carcinoma in SITU of the breast detected by screening mammography.2015
Author(s)
Ayaka S, Tomonori K, Tsutomu Y, Yoshio I, Kumiko N, Shiori S, Noriyuki Y, Jun-ichi A, Szuko M, Shu I, Tamotsu S
Organizer
27th European Congress of Pathology
Place of Presentation
セルビア
Year and Date
2015-09-05 – 2015-09-09
Int'l Joint Research
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