Investigation of the peculiar invasion/metastasis mechanism of breast invasive micropapillary carcinoma.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460425
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Kawasaki Medical School
• Principal Investigator: Kanomata Naoki 川崎医科大学, 医学部, 准教授 (60263373)
• Co-Investigator(Kenkyū-buntansha): YAMAGUCHI Rin 久留米大学, 医学部, 准教授 (10309750)
• Co-Investigator(Renkei-kenkyūsha): KUREBAYASHI Junichi 川崎医科大学, 医学部, 教授 (10248255) ; MORIYA Takuya 川崎医科大学, 医学部, 教授 (00230160)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 浸潤性微小乳頭癌 / リンパ節転移 / 免疫染色 / 乳癌

Outline of Final Research Achievements

Invasive micropapillary carcinoma has the peculiar pseudopapillary and/or micropapillary structures. Invasive micropapillary carcinoma has been known to have more lymph vessel infiltration and nodal involvement than usual invasive ductal carcinoma. However, the mechanism of invasive micropappillary carcinoma has not been well understood. By immunohistochemical method, C21orf118(BC-1514) has higher expression in invasive micropapillary carcinoma than usual invasive ductal carcinoma. CD1D and PJA2 showed their lower expression in micropapillary carcinoma than usual carcinoma. CD1D has the significant inverse correlation with venous invasion (p=0.002) and lymph node metastasis (p=0.047). CD1D might suppress lymph node metastasis.

Free Research Field

乳腺病理