Association of histological diversity and genetic alteration of gastric cancer in the elderly

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460428
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: ARAI Tomio 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (20232019)
• Co-Investigator(Renkei-kenkyūsha): IZUMIYAMA Naotaka 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 助手 (10158751)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 胃癌 / 高齢者 / ミスマッチ修復遺伝子 / マイクロサテライト不安定性

Outline of Final Research Achievements

Gastric cancer in the elderly shows histological diversity. Gastric cancer with microsatellite instability (MSI) increases with advancing age and solid-type poorly differentiated adenocarcinoma (por1) is histological type which demonstrates the highest proportion of MSI. Pathologically, the por1 cancer is closely related with older age, female predominance, lower third location and concomitant glandular component. Although gastric cancer infrequently shows KRAS and BRAF mutations, the por1 cancer demonstrated rather higher proportion of the mutations. Thus, these results suggest that the por1 cancer is a peculiar type of histology, especially in the elderly women.

Free Research Field

病理学