2015 Fiscal Year Final Research Report
Study on standardization of histopathological diagnostic criteria for submucosal invasive gastric carcinoma
| Project/Area Number |
25460463
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUGAI TAMOTSU 岩手医科大学医学部, 病理診断学講座, 教授 (20187628)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 胃粘膜下層浸潤癌 / 病理組織診断 / 粘膜筋板 / 浸潤距離 / 標準化 / バーチャルスライド |
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| Outline of Final Research Achievements |
Adaptation of the additional operation after the endoscopic treatment for the early gastric cancer was determined by histopathological diagnosis. Standardization of histopathological diagnostic criteria for submucosal invasive gastric carcinoma have been particularly important problem. In this study, the following results were revealed. 1) The morphological changes of the muscularis mucosae were histologically divided into complete maintenance type, discontinuous and ill-defined structure type and complete destruction type. 2) The morphological types of muscularis mucosae were related to clinicopathologic characteristics such as macroscopic feature, submucosal invasion depth, main histologic type of submucosal invasion area, mucin phenotype, lymphovascular invasion and lymph node metastasis. 3) The use of whole-slide imaging in histologic evaluation was possible like a conventional light microscopy and was usuful for standardization of histopathologic diagnostic criteria.
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| Free Research Field |
医歯薬学
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