Establishment of synovial sarcoma initiating cell model and exploration of new therapeutic targets

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460471
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Hokkaido University
• Principal Investigator: KIMURA TAICHI 北海道大学, 医学(系)研究科(研究院), 特任助教 (90435959)
• Co-Investigator(Kenkyū-buntansha): TANAKA SHINYA 北海道大学, 医学研究科, 教授 (70261287)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 滑膜肉腫 / 腫瘍幹細胞

Outline of Final Research Achievements

In this study, to elucidate the maintenance and regulation mechanisms of synovial sarcoma initiating cells that are closely involved in the recurrence and metastasis, we examined SS18-SSX binding proteins which were specific for sphere-forming subpopulation by mass spectrometry analysis. By proteomic analysis, we obtained specific or enhanced 26 binding protein candidates, including PARP1 and NPM, which were localized in nucleus and associated with transcriptional regulation. These results suggest that the induction of SS18-SSX and SS18-SSX binding proteins specific for sphere-forming subpopulation may play important roles of the transcriptional regulation specific for synovial sarcoma initiating cells.

Free Research Field

実験病理学