2015 Fiscal Year Final Research Report
Development of comprehensive detection methods of protozoan parasites using molecular taxonomy
| Project/Area Number |
25460514
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 分子分類 / 種内多型 / DNAバーコード / 原虫 / アメーバ属 / 鞭毛虫 / トリコモナス属 / トリパノソーマ |
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| Outline of Final Research Achievements |
A systemic screening method targeting protozoan parasites was developed, and applied the methods to various clinical examinations and molecular epidemiologic investigations. The achieved results are; (1) Lower prevalence of Entamoeba species in children with vertically transmitted HIV infection were observed in Western Kenya. (2) The genetic identification of Entamoeba polecki was confirmed from pigs in Japan and revealed its potential pathogenic role in the ulcerative colitis. (3) Genetic identification of various trichomonads species isolated from humans and related mammals were confirmed. The data showed the wide distribution of an specific genotype of Pentatrichomonas hominis among human and animals, and thus P. hominis is considered to be a zoonotic protozoan. (4) Other achievements; Clinical diagnoses of giardiasis and amebic liver access. The molecular epidemiologic investigation of Trypanosoma sp. among Japanese wild rodents could reveal the presence of T. grosi.
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| Free Research Field |
寄生虫学
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