Molecular mechanisms and control of immune cell migration to inflamed sites

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460588
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Immunology
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Hirata Takako 滋賀医科大学, 医学部, 教授 (00346199)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 炎症 / アレルギー / リンパ球 / セレクチン / ケモカイン

Outline of Final Research Achievements

Inflammatory and immune cell migration to inflamed sites is essential for host defense against pathogens, but it also plays a role in the pathogenesis of autoimmune and allergic diseases. In this research project, we investigated molecular mechanisms underlying the migration of various cell subsets to inflamed tissues, and analyzed how cell migration was regulated. We identified a novel isoform of human L-selectin encoding a soluble molecule, implicated in the functional regulation of cell surface L-selectin, which mediates immune cell migration to inflamed sites. We also clarified that selectin ligand modifying enzymes are differentially expressed in the T cell subsets that migrate to the inflamed skin. We further identified candidate molecules involved in memory T cell migration to the nasal mucosa during nasal immune responses.

Free Research Field

免疫学