2016 Fiscal Year Final Research Report
Role of IgM Fc receptor in enhancing humoral immune responses and preventing autoimmunity
| Project/Area Number |
25460604
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Wang Ji-Yang 東京医科歯科大学, 難治疾患研究所, 特任講師 (80231041)
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| Co-Investigator(Renkei-kenkyūsha) |
Ouchida Rika 東京大学, 医科学研究所, 助教 (80391887)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | IgM Fc receptor / B lymphocyte / Humoral immunity |
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| Outline of Final Research Achievements |
The following achievements were obtained: 1) The IgM Fc receptor（FcμR）physically interacts with the B cell receptor and promotes the survival and activation of antigen-stimulated B cells; 2) FcμR enhances the antibody production against foreign antigens yet suppresses autoantibody production; 3) FcμR and IgG Fc receptor (FcγR2B) compete with each other to positively and negatively regulate B cell activation; 4) FcμR is required for the normal development, maturation, activation and differentiation into antibody-producing plasma cells of the marginal zone B cells. In summary, FcμR plays a critical role in the maintenance of immune system homeostasis.
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| Free Research Field |
免疫学
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