personally customized photodynamic therapy for oral cancer patients using porphyrin synthesis protein as a biomarker

2016 Fiscal Year Final Research Report

• Project/Area Number: 25460680
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Nagata Tetsuji 浜松医科大学, 医学部附属病院, 講師 (60264058)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 口腔がん / プロトポルフィリン

Outline of Final Research Achievements

It is known that the oral cancer lesion is activated by blue-light irradiation and emits red fluorescence. We focused on efficacy of the photodynamic therapy using 5-aminolevulinic acid (ALA), and analyzed the red fluorescent expression by protoporphyrin IX(PpIX) in the tumor of of the oral cavity. As a result, approximately 40% of the tumors of oral cavity lesion emitted red fluorescence. The red fluorescence was distributed over the tumor region heterogeneously, and there was no association with the differentiation nor the histologic type of the tumor. We need to investigate a red fluorescent origin, and seek a factor to raise the effect of photodynamic therapy.

Free Research Field

歯科口腔外科