Molecular mechanisms of knee pain associated with osteoarthritis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460716
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pain science
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: JU YOUNG-JIN 東京医科歯科大学, 医学部附属病院, 非常勤講師 (10436636)
• Co-Investigator(Kenkyū-buntansha): TSUJI KUNIKAZU 東京医科歯科大学, 医歯学総合研究科, 准教授 (20323694) ; MUNETA TAKESHI 東京医科歯科大学, 医歯学総合研究科, 教授 (50190864) ; TSUJI KUNIKAZU 東京医科歯科大学, 再生医療研究センター, 教授 (10345291) ; AKAZAWA CHIHIRO 東京医科歯科大学, 保健衛生学研究科, 教授 (80291160)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 変形性膝関節症 / 疼痛

Outline of Final Research Achievements

This study was aimed to analyze the molecular mechanisms of joint pain associated with knee osteoarthritis. In this study we reported that intra-articular injection of mesenchymal stem cells isolated from syonovial membrane in the knee joint had chondroprotective and anti-inflammatory effects in monoiodoacetic acid (MIA)-induced osteoarthritis model in rats. In addition, we reported that joint pain induced by the intra-articular injection of MIA was significantly alleviated by the intra-articular injection of mesenchymal stem cells. This effect was observed only when we injected mesenchymal stem cells in the acute phase (within 1 to 5 days) of joint inflammation induced by MIA injection. These data suggest that mesenchymal stem cells might have some inhibitory effects on the pro-inflammatory mediators functioning in the immediate early stage after joint injury.

Free Research Field

整形外科学