2015 Fiscal Year Final Research Report
Elucidation of roles of spinal glial cells in intractable itch and development of antipruritic therapy
| Project/Area Number |
25460727
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Tominaga Mitsutoshi 順天堂大学, 医学研究科, 准教授 (50468592)
Kamo Atsuko 順天堂大学, 医学研究科, 助教 (50614088)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 難治性かゆみ / ミクログリア / アトピー性皮膚炎 / 脊髄 / ミノサイクリン |
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| Outline of Final Research Achievements |
This study was performed to investigate role of spinal glial cells, especially microglia, in intractable itch of atopic dermatitis (AD) using NC/Nga mouse, an AD model. Intrathecal injection of minocycline (an inhibitor of microglia) suppressed scratching behavior and improved the dermatitis scores through inhibition of increase of spinal microglia. Thus, this finding suggests that spinal microglial cell is one of antipruritic targets in AD.
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| Free Research Field |
皮膚科学、かゆみ科学
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