Epidemiological study on the genetic polymorphisms and methylation effects of physical activity for lifestyle disease prevention

2016 Fiscal Year Final Research Report

• Project/Area Number: 25460759
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Saga University
• Principal Investigator: Hara Megumi 佐賀大学, 医学部, 准教授 (90336115)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 遺伝子損傷 / 身体活動 / メチル化

Outline of Final Research Achievements

Genetic damage due to reactive oxygen species increases with age and contributes to the onset of cancer. In this study, we examined the relationship between physical activity and DNA damage, and DNA damage repair gene methylation. The concentration of urinary 8-hydroxdeoxyguanosine (8-OHdG), a DNA damage marker, was negatively correlated with the total body activity level in females and negatively correlated with mid- to high-intensity physical activity levels in males. On the other hand, DNA methylation in the promoter region of 8-oxoguanine DNA glycosylase 1 (hOGG1), a gene damage repair enzyme, was positively correlated with the amount of physical activity. Higher amount of physical activity increases endogenous antioxidant capacity and DNA damage decreases. Conversely, DNA damage increases when the amount of physical activity is low, so the promoter region of DNA is low in order to express hOGG1 Suggesting the possibility of methylation.

Free Research Field

疫学