Factors involved in exacerbation of inflammation of metabolic syndrome and risk prediction using biomarkers

2016 Fiscal Year Final Research Report

• Project/Area Number: 25460811
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Wakayama Medical University
• Principal Investigator: Takeshita Tatsuya 和歌山県立医科大学, 医学部, 教授 (20150310)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 飲酒 / 多型 / アルコール脱水素酵素 / アルデヒド脱水素酵素 / アセトアルデヒド / アディポネクチン

Outline of Final Research Achievements

We examined relationships between the ALDH2 and ADH1B genotypes, alcohol drinking behavior and serum adiponectin levels in 541 male workers. Total serum adiponectin, high molecular weight adiponectin levels in heavy drinkers (more than or equal to 12 units or more per week) were significantly lower than non- or light drinkers.
We examined relationships between the ALDH2 and ADH1B genotypes and alcohol sensitivity (facial flushing) or alcohol drinking behavior in 718 men (357 middle-aged and 361 older). We observed significant difference in alcohol sensitivity and alcohol drinking behavior only in the older men.

Free Research Field

医歯薬学