Anti-tumor effects of EGFR inhibitors via cell differentiation on esophageal cancer cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460926
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyoto University
• Principal Investigator: Ohashi Shinya 京都大学, 医学(系)研究科(研究院), 助教 (20435556)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 食道癌 / EGFR阻害剤 / 分化誘導

Outline of Final Research Achievements

Cytotoxic and anti-tumor effects of EGFR inhibitors on human (esophageal squamous cell carcinoma) ESCC cells (TE1, TE5, TE8, TE11R, and HCE4) as well as transformed esophageal epithelial cells (T-Epi, T-Mes) were investigated. EGFR inhibitors showed cytotoxic and anti-tumor effect on epithelial-like cells (TE1, TE5, TE11, TE11R, and T-Epi) in accompany with increased expression of cell differentiation markers, but not on mesenchymal-like cells (TE8, HCE4, and T-Mes). EGFR inhibitors are considered to be effective for epithelial-like ESCC cells through the induction of cell differentiation.

Free Research Field

消化器内科