Effect of intra-venous corticotropin releasing hormone (CRH) on esophageal physiological changes in NERD patients.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460940
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Hyogo Medical University
• Principal Investigator: Miwa Hiroto 兵庫医科大学, 医学部, 教授 (80190833)
• Co-Investigator(Kenkyū-buntansha): OSHIMA Tadayuki 兵庫医科大学, 医学部, 講師 (00381814) ; TOMITA Toshihiko 兵庫医科大学, 医学部, 講師 (60388824) ; YAMASAKI Takahisa 兵庫医科大学, 医学部, 助教 (80648791)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: CRH / 食道知覚閾値 / 非びらん性胃食道逆流症(NERD)

Outline of Final Research Achievements

We investigated whether intra-venous corticotropin releasing hormone (CRH) administration increases esophageal sensitivity by electrical stimulation in healthy subjects and NERD patients. To evaluate electrical sensitivity, an electrode was inserted and placed above the upper boarder of the lower esophageal sphincter (LES). The electrical stimulation was gradually increased. We quantified the initial perception threshold (IPT: the minimum current intensity at which the subject first perceived the stimulus). After determination of the baseline IPT, we intravenously administered CRH. As a result, CRH significantly decreased electrical threshold of the esophagus after CRH injection in both healthy subjects and NERD patients, thus suggesting that CRH increased esophageal sensitivity to the electrical stimulus.

Free Research Field

消化管