Role of Macrophage migration inhibitory factor in non-alcoholic steatohepatitis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460968
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Hokkaido University
• Principal Investigator: OHKAWARA Tatsuya 北海道大学, 薬学研究科(研究院), 研究員 (00374257)
• Co-Investigator(Kenkyū-buntansha): TAKEDA Hiroshi 北海道大学, 薬学研究院臨床病態解析学, 教授 (60261294) ; OHNISHI Shunsuke 北海道大学, 大学病院, 講師 (10443475)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: マクロファージ遊走阻止因子 / 非アルコール性脂肪性肝炎 / 薬剤性肝障害 / コリン・メチオニン欠損食 / アセトアミノフェン

Outline of Final Research Achievements

We investigate the role of macrophage migration inhibitory factor (MIF) in non alcoholic steatohepatitis (NASH) using animal model. Methionine and choline-deficient diet(MCD) induces NASH in mice. The expression of MIF was up-regulated in liver of mice given MCD. However, ISO-1, an inhibitor of MIF bioactivity, did not ameliorated the severity of NASH in mice. In another hepatitis model induced by acetaminophene, ISO-1 reduced the severity of liver injury and decrease the level of inflammatory mediater. Taken together, our data suggest that the role of MIF is perplexing in NASH.

Free Research Field

消化器病学