2015 Fiscal Year Final Research Report
Iron overload by iron metabolism dysregulation and UPR breakdown through the ER stress
| Project/Area Number |
25460969
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Katsunori 旭川医科大学, 医学部, 特任教授 (60336394)
TANAKA Hiroki 旭川医科大学, 医学部, 助教 (70596155)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 脂肪肝 / 鉄代謝異常 |
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| Outline of Final Research Achievements |
Non-alcoholic fatty liver disease frequently coexist iron overload. Iron dysregulation by hepcidin down-regulation is considered to be the cause as same as hereditary heamochromatosis. Bone morphogenetic protein binding endothelial regulator (BMPER) is inhibiting BMP-SMAD signaling by binding BMP extracellularly, subsequently reduces hepcidin transcription. Although BMPER was thought to be expressed by hepatocytes because of its vast protein expressing functions, it is noteworthy that we found out BMPER is expressed dominantly in liver sinusoid endothelial cells rather than hepatocytes.
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| Free Research Field |
肝臓病学
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