Elucidation of the common mechanisms of tissue remodeling in nonalcoholic steatohapatitis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460990
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Mie University
• Principal Investigator: Takei Yoshiyuki 三重大学, 医学(系)研究科(研究院), 教授 (10306954)
• Co-Investigator(Kenkyū-buntansha): GABAZZA Esteban 三重大学, 医学(系)研究科(研究院), 教授 (00293770) ; IWASA Motoh 三重大学, 医学(系)研究科(研究院), 准教授 (80378299) ; FUJITA Naoki 三重大学, 医学(系)研究科(研究院), リサーチアソシエイト (80378398)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 脂肪性肝炎 / 動脈硬化症 / 凝固・線溶系 / 組織リモデリング / protein S

Outline of Final Research Achievements

In this study, we elucidated that Protein S (PS) exacerbates steatohepatitis by stimulating natural killer T and inhibiting apoptosis of the cell type. Atherosclerosis caused by ethanol is associated with activation of the coagulation system and decreased circulating levels of stromal cell-derived factor-1. These data collectively indicate that derangement of the coagulation and fibrinolysis system contributes to pathogenesis of not only steatohepatitis but atherosclerosis. This suggests that the coagulation and fibrinolysis system is a new therapeutic target for steatohepatistis and its complication, atherosclerosis.

Free Research Field

消化器内科学