The investigation of contribution of incretin to the pathogenesis of NASH

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460999
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kochi University
• Principal Investigator: Okamoto Nobuto 高知大学, 教育研究部医療学系臨床医学部門, 講師 (10346710)
• Co-Investigator(Kenkyū-buntansha): SAIBARA Toshiji 高知大学, 教育研究部医療学系臨床医学部門, 教授 (60145125) ; ONO Masafumi 高知大学, 教育研究部医療学系臨床医学部門, 准教授 (70304681)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 肝臓学 / 非アルコール性脂肪肝炎 / インクレチン / GLP-1 receptor

Outline of Final Research Achievements

The direct mechanisms of contribution of incretin to hepatocytes on the pathogenesis of nonalcoholic steatohepatitis (NASH) was investigated. We found GLP-1 receptor (GLP-1R) expressed on the hepatocytes. It was clarified that incretin contributed glucose metabolisms and pathogenesis of NASH by overexpression of GLP-1R on hepatocytes. In addition, it was clarified that this system had close talk with insulin signal, IRS-1, -2, and had important roles for the glucose metabolisms in liver.

Free Research Field

消化器病学