2015 Fiscal Year Final Research Report
The mechanism of mitochondrial injury and iron overload induced hepatocarcinogenesis in the post hepatic virus.
| Project/Area Number |
25461019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | National Center for Global Health and Medicine |
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Principal Investigator |
korenaga Masaaki 国立研究開発法人国立国際医療研究センター, その他部局等, その他 (70420536)
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| Co-Investigator(Kenkyū-buntansha) |
MURATA KAZUMOTO 国立研究開発法人国立国際医療研究センター, その他部局等, その他 (40345971)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 酸化ストレス / ミトコンドリア障害 / 脂肪肝 / 鉄過剰 |
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| Outline of Final Research Achievements |
The inhibition of COX7a2 in mitochondrial complex IV might induce hepatic oxidative stress, fat accumulation, and iron metabolic disorder.Deferasirox improved hepatic ballooning reduced liver fibrosis in STAM miceHowever, long term treatment of Deferasirox could not inhibit the development of liver tumors.
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| Free Research Field |
肝臓病学
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