Extracorporeal low-energy shock wave therapy exerts anti-inflammatory effects in a rat model of acute myocardial infarction

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461099
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Tohoku University
• Principal Investigator: Ito Kenta 東北大学, 医学(系)研究科(研究院), 准教授 (50375086)
• Co-Investigator(Kenkyū-buntansha): Shimokawa Hiroaki 東北大学, 大学院医学系研究科, 教授 (00235681) ; Kawakami Kazuyoshi 東北大学, 大学院医学系研究科, 教授 (10253973)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 低出力体外衝撃波治療 / 血管新生 / 急性心筋梗塞 / 左室リモデリング / 抗炎症作用

Outline of Final Research Achievements

It has been previously demonstrated that extracorporeal low-energy shock-wave (SW) therapy ameliorates left ventricular (LV) remodeling through enhanced angiogenesis after acute myocardial infarction (AMI) in pigs in vivo. However, it remains to be examined whether SW therapy also exerts anti-inflammatory effects on AMI.
In the present study, we have reported that low-energy shock wave therapy suppressed post-MI LV remodeling in rats in vivo, which was associated with anti-inflammatory effects in addition to its angiogenic effects.

Free Research Field

循環器病学