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2015 Fiscal Year Final Research Report

Theoretical studies on ablation targets and optimal approach of chronic atrial fibrillation treatment.

Research Project

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Project/Area Number 25461106
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionShiga University of Medical Science

Principal Investigator

Ashihara Takashi  滋賀医科大学, 医学部, 助教(学内講師) (80396259)

Co-Investigator(Kenkyū-buntansha) OZAWA Tomoya  滋賀医科大学, 医学部, 助教 (20584395)
HARAGUCHI Ryo  国立研究開発法人国立循環器病研究センター, 情報統括部, 室長 (00393215)
INADA Shin  国立研究開発法人国立循環器病研究センター, 研究情報基盤管理室, 研究員 (50349792)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywords分子心臓学 / 不整脈学
Outline of Final Research Achievements

The mechanisms underlying complex fractionated atrial electrogram (CFAE)-targeted chronic atrial fibrillation (CAF) ablation are poorly understood. To provide theoretical bases for the CAF ablation strategies, we developed a computer model of human CAF, conducted simulation of CFAE, and tried to propose optimal strategy for the CAF ablation. Then we found that fibroblast proliferation in atria causes the sustainment of the rotors (spiral wave reentries) during CAF, and success or failure of CAF ablation is determined by the balance of rotor increase or decrease. In addition, the knowledge obtained in this study was applied to the development of real-time phase mapping system of human CAF.

Free Research Field

循環器学(不整脈学),医用生体工学

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Published: 2017-05-10  

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