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2015 Fiscal Year Final Research Report

The great earthquake stress is associated to dysregulation of atherosclerosis-related genes in general population.

Research Project

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Project/Area Number 25461138
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionIwate Medical University

Principal Investigator

Satoh Mamoru  岩手医科大学, 医学部, 准教授 (90305996)

Co-Investigator(Kenkyū-buntansha) ITOH Tomonori  岩手医科大学, 医学部, 教授 (30347851)
MAESAWA Chihaya  岩手医科大学, 医学部, 教授 (10326647)
ISHIKAWA Yuh  岩手医科大学, 医学部, 助教 (20583537)
HACHIYA Tsuyoshi  岩手医科大学, いわて東北メディカル・メガバンク機構, 准教授 (20580088)
SHIWA Yu  岩手医科大学, いわて東北メディカル・メガバンク機構, 講師 (00647753)
Project Period (FY) 2013-04-01 – 2016-03-31
KeywordsDNAメチル化 / Small RNA / 動脈硬化性疾患 / 震災ストレス
Outline of Final Research Achievements

It has been already known that serial disasters, such as the great earthquake, is relate to an increased number of patients with coronary artery disease. Indeed, the number of patients with failing heart increased after the Great East Japan Earthquake (Nakamura et al. Am J Cardiol 2012). This study has investigated that the earthquake stress induces DNA methylation of atherosclerosis-related genes and abnormal profiling of small non-coding RNAs and then may be involve in the pathogenesis of atherosclerotic dieases.

Free Research Field

循環器内科

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Published: 2017-05-10  

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