2015 Fiscal Year Final Research Report
Elucidation of the mechanism of development of different types of aneurysm
| Project/Area Number |
25461142
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Juntendo University (2014-2015)
National Defense Medical College (2013) |
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Principal Investigator |
Isoda Kikuo 順天堂大学, 医学部, 准教授 (00532475)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 動脈瘤 / 炎症 / サイトカイン / 骨髄 / DPP-4阻害 |
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| Outline of Final Research Achievements |
We detected that the IL-1Ra present in both bone marrow (BM)-derived cells and non-BM cells helps to suppress arterial inflammation and promote re-endothelialization, thus resulting in decreased neointimal formation and development of aneurysm. These novel findings shed new light on the mechanisms underlying the development of aneurysm. We also revealed that a dipeptidyl‐peptidase‐4 inhibitor appeared to suppress neointimal formation by inhibiting inflammation, independently of its effects on glucose or cholesterol metabolism in mice. We have published these articles.
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| Free Research Field |
分子血管学
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