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2015 Fiscal Year Final Research Report

Comprehensive analysis of risk factors for asthma and COPD by prospective cohort study

Research Project

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Project/Area Number 25461147
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionUniversity of Tsukuba

Principal Investigator

Sakamoto Tohru  筑波大学, 医学医療系, 准教授 (50282356)

Co-Investigator(Kenkyū-buntansha) HIZAWA NOBUYUKI  筑波大学, 医学医療系, 教授 (00301896)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywords喘息 / 慢性閉塞性肺疾患 / 前向き研究 / 遺伝子多型
Outline of Final Research Achievements

A follow-up survey of 1312 healthy volunteers for 5 years demonstrated 35 new-onset asthma and 11 COPD patients. FEV1/FVC in the COPD group was significantly lower than that in the control group. Heretabilities for %FVC, %FEV1, and FEV1/FVC were estimated to be 71, 52, and 42%, respectively. Then, genome-wide association study using the healthy volunteers and asthma patients suggested that HAS2 and HCG22 are associated with the development of asthma.

Free Research Field

呼吸器内科学

URL: 

Published: 2017-05-10  

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